BEAMing and mCRC

Directing Therapy

Tabernero J, Lenz HJ, Siena S, et al.(2015) Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial. Lancet Oncol. 16(8):937-48.
Pubmed

Van Cutsem E, Lenz HJ, Köhne CH, et al. (2015) Fluorouracil, leucovorin, and irinotecan plus cetuximab treatment and RAS mutations in colorectal cancer. J Clin Oncol.33(7):692-700.
Pubmed
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Bokemeyer C, Köhne CH, Ciardiello F, et al. (2015) FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer. Eur J Cancer 51(10):1243-52.
Pubmed 

Sorich MJ, Wiese MD, Rowland A et al. (2015) Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: a meta-analysis of randomized, controlled trials. Ann Oncol. 26(1):13-21.
Pubmed
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Ciardiallo F, Lenz HJ, Koehne CH, et al.(2014) Treatment outcome according to tumor RAS mutation status in CRYSTAL study patients with metastatic colorectal cancer (mCRC) randomized to FOLFIRI with/without cetuximab.  J Clin Oncol.  2014 ASCO Annual Meeting Abstracts.Vol 32, No 15_suppl
Abstract

Monitoring resistance

Morelli MP, Overman MJ, Dasari A et al. (2015) Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment. Ann Oncol. 26(4):731-6.
Pubmed

Misale S, Yaeger R, Hobor S, et al. (2012) Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486(7404):532-6
Pubmed
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Diaz L, Williams R, Wu J, et al. (2012) The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486(7404):537-40
Pubmed
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Diehl F, Schmidt K, Choti, M, et al. (2008) Circulating mutant DNA to assess tumor dynamics. Nat Med. 14(9):985-90.
Pubmed
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Our BEAMing Technology

Principle of Blood-based Testing

The value of ctDNA

Publications

The BEAMing technology

Method papers

The BEAMing technology

Concordance studies

BEAMing and NSCLC

Publications

BEAMing and Breast cancer

Publications

BEAMing and Melanoma

Publications

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