Plasma SafeSeq NGS technology

Ultrasensitive sequencing for the detection of low abundant mutant DNA

Plasma-Sequencing (Plasma-Seq) is a unique approach combining next generation sequencing technology with Sysmex Inostics expertise for highly sensitive mutation detection in plasma DNA.

Quick Facts

  • The Plasma-Seq technology has an average sensitivity for rare variants around 0.02%
  • Plasma-Seq allows quantification of absolute abundance of normal and mutant alleles
  • Multiplex amplification offers flexibility to combine different target regions
  • Discovery of de novo mutations possible
  • Plasma-Seq works without enrichment of mutant or depletion of wild-type DNA molecules


  • Identification of variants linked to tumor status and drug resistance
  • Mutation analysis of tumor suppressor genes
  • Pathway analysis  



  1. Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Kinde I, Bettegowda C, Wang Y, Wu J, Agrawal N, Shih IeM, Kurman R, Dao F, Levine DA, Giuntoli R, Roden R, Eshleman JR, Carvalho JP, Marie SK, Papadopoulos N, Kinzler KW, Vogelstein B, Diaz LA Jr (2013) Sci Transl. Med. 9;5(167):167ra4.
  2. Detection and quantification of rare mutations with massively parallel sequencing. Kinde I, Wu J, Papadopoulos N, Kinzler KW, Vogelstein B (2011) Proc Natl Acad Sci U S A. 108(23):9530-5.  



Our BEAMing Technology

Principle of Blood-based Testing

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