SafeSEQ Testing

We at Sysmex Inostics recognize that one size does not fit all when it comes to next-generation sequencing solutions for oncology.

Large pan-cancer tests excel at investigation into novel markers.  However, once the most relevant set of targets for a clinical application has been defined, pan-cancer testing does not make sense when only a small subset of the large panel is required.

It is also becoming increasingly clear that large NGS panels designed primarily for therapy selection do not meet the performance requirements for emerging clinical applications such as molecular monitoring of minimal residual disease using ctDNA.

Our SafeSEQ services for biopharma oncology programs bring the performance of Sysmex Inostics' OncoBEAM enhanced digital PCR technology to a unique NGS approach that prioritizes clinical relevance, quality and reliability of data, and economics.

Choose from a purpose-designed panel optimized to meet a specific clinical need, or request a rapid customization solution to ensure you have the right test for the right need.

ER+/HER2- Breast cancer

  • Novel therapeutic targets in the AKT1/PIK3CA signaling pathway
  • Putative resistance mutations affecting HER2, ESR1, and KRAS
  • "Truncal" mutation coverage across AKT1, PIK3CA, and TP53 for recurrence monitoring                                          Learn More (pdf) →

Colorectal cancer

Molecular minimal residual disease (MRD) detection via ctDNA using mutations in AKT1, APC, BRAF, CTNNB1, ERBB3, FBXW7, KRAS, NRAS, PIK3CA, POLE, PPP2R1A, RNF43, SMAD4, and TP53 as surrogate markers for disease status

Head and neck squamous cell carcinoma

  • Novel putative therapeutic targets HRAS & PIK3CA
  • "Truncal" mutation coverage across CDKN2A, TP53
  • Designed for molecular analysis of HPV(-) HNSCC

Learn More (pdf) →

SafeSEQ Rapid Customization

SafeSEQ is customizable according to your requirements (e.g. sample type, panel design, sensitivity level) to ensure you have the most efficient test available for your clinical development program. Please contact your local Sysmex Inostics sales representative or use our contact form for more information.