OncoBEAM™ IDH2

  • The OncoBEAM™ IDH2 test is a bead-based digital PCR approach (also called BEAMing Digital PCR) allowing for the detection of up to 5 different mutations from a single sample.
  • Mutations covered:
    R140W, R140Q, R140L, R172K, R172M

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Isocitrate dehydrogenase 2 (IDH2) gene encodes a NADP+-dependent isocitrate dehydrogenases involved in the regulation of oxidative respiration (1).

Somatic mutations of the IDH2 gene have recently been identified in multiple cancers including early- and late-stage glioma (2-3), sarcoma (4-5), acute myeloid leukemia (AML; 6-7), and others. Notably, all mutations map to arginine residues in the catalytic pockets of IDH2 (R140, R172). Particularly the recent discovery of a gain-of-function somatic mutation in gliomas and its potential role in disease pathogenesis and prognosis has made IDH2 both a promising biomarker and potential therapeutic target (8-9).

 

* RESEARCH USE ONLY. Not intended for use in diagnostic procedures.

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Mutations

Mutations

Cancer Relevance

Cancer Relevance

  • Glioma
  • Sarcoma
  • Acute Myeloid Leukemia (AML)
Test Details

Test Details

Turn around times

  • Batch analysis <4 weeks
  • Single samples < 10 days

Sample Requirements

  • Serum/Plasma
    ≥ 2 ml
  • Whole blood
    10 ml
  • FFPE/Frozen Tissue
    3 sections at 5 μm
References

References

  1. Reitman ZJ and Yan H (2010) J Natl Cancer Inst (2010) 102(13): 932-941
  2. Parsons DW et al. (2008) Science 321 (5897): 1807-1812
  3. Yan H et al. (2009) N. Engl. J. Med. 360(8):765-73
  4. Amary MF et al. (2011) J. Pathol. 224(3):334-43
  5. Borger DR et al. (2012) Oncologist17(1):72-9
  6. Paschka P et al. (2010) J. Clin. Oncol. 28(22):3636-43
  7. Green A et al.(2010) N Engl J Med 2010; 362:369-370
  8. Guo C et al. (2011) Curr Opin Neurol 24(6):648-52
  9. Wang F et al. (2013) Science 340 (6132): 622-626
  10. Waitkus MS et al. (2016) Neuro Oncol 18 (1): 16‐26
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info@sysmex-inostics.com

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