OncoBEAMTM liquid biopsy tests utilize BEAMing technology (Beads, Emulsions, Amplification & Magnetics), which is an ultra-sensitive method specifically designed for circulating tumor DNA (ctDNA) analysis. The BEAMing method employs an optimized digital PCR technique combined with flow cytometry that ensures each molecule of input DNA is analyzed to ensure reliable detection of rare mutant molecules.
OncoBEAMTM was the first established digital PCR technology platform for liquid biopsy and has been used to advance both clinical validity and utility of plasma-based detection of various clinically-relevant mutations across a number of cancer types such as non-small cell lung cancer, colorectal cancer, and estrogen receptor-positive/ HER2-negative breast cancer.
We offer the following OncoBEAMTM assays to support development of targeted therapies, as well as exploration of novel clinical applications for ctDNA such as molecular monitoring of treatment response and minimal/measurable residual disease (MRD). These assays are available for prospective testing in CLIA/GCP environments.
GENES | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
IDH1 | 4 | 132 | R132S [394C>A], R132G [394C>G], R132C [394C>T], R132H [395G>A], R132L [395G>T] |
IDH2 | 4a | 140 | R140W [418C>T], R140Q [419G>A], R140L [419G>T] |
4b | 172 | R172K [515G>A], R172M [515G>T] |
GENES | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
AKT1 | 2 | 17 | E17K [49G>A] |
ESR1 | 5 | 380 | E380Q [1138G>C] |
7 | 463 | S463P [1387T>C] | |
8 | 534, 535, 536, 537, 538 | V534E [1601T>A], P535H [1604C>A], L536H [1607T>A], L536P [1607T>C], L536R [1607T>G], L536Q [1607_1608delinsAG], Y537N [1609T>A], Y537S [1610A>C], Y537C [1610A>G], D538G [1613A>G] | |
PIK3CA | 7 | 420 | C420R [1258T>C] |
9 | 542, 545, 546 | E542K [1624G>A], E545G [1634A>G], E545K [1633G>A], Q546K [1636C>A] | |
20 | 1043, 1047 | M1043I [3129G>T], H1047R [3140A>G], H1047L [3140A>T], H1047Y [3139C>T] |
Additional mutations are available in PIK3CA(10,20)/AKT1(2)/ BRAF(15). For detailed information contact your local key Account Manager or drop us a line via info@sysmex-inostics.com
GENES | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
KRAS | 2 | 12,13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D [35G>A], G12A [35G>C], G12V [35G>T], G13D [38G>A] |
3 | 59, 61 | A59T [175G>A], Q61H [183A>C, 183A>T], Q61L [182A>T] | |
4 | 117, 146 | K117N [351A>C, 351A>T], A146T [436G>A], A146V [437C>T] | |
NRAS | 2 | 12,13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D [35G>A], G12A [35G>C], G12V [35G>T], G13R [37G>C], G13D [38G>A], G13V [38G>T] |
3 | 59, 61 | A59T [175G>A], Q61H [183A>C, 183A>T], Q61R [182A>G], Q61L [182A>T], Q61K [181C>A] | |
4 | 117, 146 | K117N [351C>A, 351A>T], A146T [436G>A] | |
BRAF | 15 | 600 | V600E [1799T>A] |
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
PIK3CA | 10 | 542, 545, 546 | E542K [1624G>A],E545G [1633G>A], E545K [1634A>G], Q546K [1636C>A] |
20 | 1043, 1047 | M1043I [3129G>T], H1047R [3140A>G], H1047L[3140A>T], H1047Y[3139C>T] | |
AKT1 | 2 | 17 | E17K [49G>A] |
BRAF | 15 | 600 | V600K [1798_1799delinsAA] |
GENES | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
IDH1 | 4 | 132 | R132S [394C>A], R132G [394C>G], R132C [394C>T], R132H [395G>A], R132L [395G>T] |
IDH2 | 4a | 140 | R140W [418C>T], R140Q [419G>A], R140L [419G>T] |
4b | 172 | R172K [515G>A], R172M [515G>T] |
GENES | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
BRAF | 15 | 600 | V600E [1799T>A] |
EGFR | 19 | 746, 747 | E746_A750del [2235_2249del, 2236_2250del], E746_S752>V [2237_2255delinsT], L747_A750>P [2239_2248delinsC], L747_T751del [2240_2254del], L747_P753>S [2240_2257del] |
20 | 790, 797 | T790M [2369C>T], C797S [2389T>A, 2390G>C] | |
21 | 858, 861 | L858R [2573T>G], L861Q [2582T>A] | |
KRAS | 2 | 12, 13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D[35G>A], G12A [35G>C], G12V [35G>T], G13D [38G>A] |
3 | 61 | Q61L [182A>T], Q61H [183A>T, 183A>C] |
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
BRAF | 15 | 600 | V600E [1799T>A], V600K [1798_1799delinsAA] |
NRAS | 3 | 61 | Q61H [183A>C, 183A>T], Q61R [182A>G], Q61L [182A>T], Q61K [181C>A] |
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
KRAS | 2 | 12,13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D [35G>A], G12A [35G>C], G12V [35G>T], G13D [38G>A] |
3 | 59, 61 | A59T [175G>A], Q61H [183A>C, 183A>T], Q61L [182A>T] | |
4 | 117, 146 | K117N [351A>C, 351A>T], A146T [436G>A], A146V [437G>T] | |
NRAS | 2 | 12,13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D [35G>A], G12A [35G>C], G12V [35G>T], G13R [37G>C], G13D [38G>A], G13V [38G>T] |
3 | 59, 61 | A59T [175G>A], Q61H [183A>C, 183A>T], Q61R [182A>G], Q61L [182A>T], Q61K [181C>A] | |
4 | 117, 146 | K117N [351C>A, 351A>T], A146T [436G>A] |
GENES | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
AR | 4 | 702, 716 | L702H [2105T>A], L702Q [2104_2106delinsACC, 2104_2106delinsACG, 2104_2106delinsACT, 2104_2106delinsACA], V716M [2148G>A] |
5 | 742 | W742L [2225G>T], W742C [2226G>T] | |
8 | 875, 877, 878, 896 | H875Y [2623C>T], F877L [2629T>C, 2631C>A, 2631C>G], T878A [2632A>G], T878S [2633C>G], M896V [2686A>G], M896T [2687T>C] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
2 | 17 | E17K [49G>A] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
22 | 1151, 1152, 1156 | T1151dup [3451_3453dup], L1152R [3455T>G], C1156Y [3467G>A] |
23 | 1171 | I1171N [3512T>A, 3512_3213delinsAT], I1171T[3512T>C], I1171S [3512T>G] |
24a | 1174, 1180 | F1174C [3521T>G], F1174L [3522C>A], V1180L [3538G>C] |
24b | 1196, 1198, 1202, 1203, 1206 | L1196M [3586C>A], L1198F [3592C>T], G1202R [3604G>A], D1203N [3607G>A], S1206Y [3617C>A] |
25 | 1296, 1275 | G1269A [3809G>C], R1275Q [3824G>A] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
4 | 702, 716 | L702H [2105T>A], L702Q [2104_2106delinsACC, 2104_2106delinsACG, 2104_2106delinsACT, 2104_2106delinsACA], V716M [2148G>A] |
5 | 742 | W742L [2225G>T], W742C [2226G>T] |
8 | 875, 877, 878, 896 | H875Y [2623C>T], F877L [2629T>C, 2631C>A, 2631C>G], T878A [2632A>G], T878S [2633C>G], M896V [2686A>G], M896T [2687T>C] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
15 | 600 | V600E [1799T>A], V600K [1798_1799delinsAA] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
19 | 746, 747 | E746_A750del [2235_2249del, 2236_2250del], E746_S752>V [2237_2255delinsT], L747_A750>P [2239_2248delinsC], L747_T751del [2240_2254del], L747_P753>S [2240_2257del] |
20 | 790, 797 | T790M [2369C>T], C797S [2389T>A, 2390G>C] |
21 | 858, 861 | L858R [2573T>G], L861Q [2582T>A] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
5 | 380 | E380Q [1138G>C] |
7 | 463 | S463P [1387T>C] |
8 | 534, 535, 536, 537, 538 | V534E [1601T>A], P535H [1604C>A], L536H [1607T>A], L536P [1607T>C], L536R [1607T>G], L536Q [1607_1608delinsAG], Y537N [1609T>A], Y537S [1610A>C], Y537C [1610A>G], D538G [1613A>G] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
4 | 132 | R132S [394C>A], R132G [394C>G], R132C [394C>T], R132H [395G>A], R132L [395G>T] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
4a | 140 | R140W [418C>T], R140Q [419G>A], R140L [419G>T] |
4b | 172 | R172K [515G>A], R172M [515G>T] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
2 | 12, 13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D [35G>A], G12A [35G>C], G12V [35G>T], G13D [38G>A] |
3 | 59, 61 | A59T [175G>A], Q61H [183A>C, 183A>T], Q61L [182A>T] |
4 | 117, 146 | K117N [351A>C, 351A>T], A146T [436G>A], A146V [437C>T] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
2 | 12, 13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D [35G>A], G12A [35G>C], G12V [35G>T], G13R [37G>C], G13D [38G>A], G13V [38G>T] |
3 | 59, 61 | A59T [175G>A], Q61H [183A>C, 183A>T], Q61R [182A>G], Q61L [182A>T], Q61K [181C>A] |
4 | 117, 146 | K117N [351C>A, 351A>T], A146T [436G>A] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
7 | 420 | C420R [1258T>C] |
9 | 542, 545, 546 | E542K [1624G>A], E545G [1634A>G], E545K [1633G>A], Q546K [1636C>A] |
20 | 1043, 1047 | M1043I [3129G>T], H1047R [3140A>G], H1047L [3140A>T], H1047Y [3139C>T] |
Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|
38 | 2032 | G2032R [6094G>A] |
40 | 2092 | Y2092C [6275A>G] |
41 | 2155 | L2155S [6464T>C] |
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
AKT1 | 2 | 17 | E17K [49G>A] |
ESR1 | 5 | 380 | E380Q [1138G>C] |
7 | 463 | S463P [1387T>C] | |
8 | 534, 535, 536, 537, 538 | V534E [1601T>A], P535H [1604C>A], L536H [1607T>A], L536P [1607T>C], L536R [1607T>G], L536Q [1607_1608delinsAG], Y537N [1609T>A], Y537S [1610A>C], Y537C [1610A>G], D538G [1613A>G] | |
PIK3CA | 7 | 420 | C420R [1258T>C] |
9 | 542, 545, 546 | E542K [1624G>A], E545G [1634A>G], E545K [1633G>A], Q546K [1636C>A] | |
20 | 1043, 1047 | M1043I [3129G>T], H1047R [3140A>G], H1047L [3140A>T], H1047Y [3139C>T] |
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
ALK | 22 | 1151, 1152, 1156 | T1151dup [3451_3453dup], L1152R [3455T>G], C1156Y [3467G>A] |
23 | 1171 | I1171N [3512T>A, 3512_3213delinsAT], I1171T[3512T>C], I1171S [3512T>G] | |
24a | 1174, 1180 | F1174C [3521T>G], F1174L [3522C>A], V1180L [3538G>C] | |
24b | 1196, 1198, 1202, 1203, 1206 | L1196M [3586C>A], L1198F [3592C>T], G1202R [3604G>A], D1203N [3607G>A], S1206Y [3617C>A] | |
25 | 1296, 1275 | G1269A [3809G>C], R1275Q [3824G>A] | |
ROS1 | 38 | 2032 | G2032R [6094G>A] |
40 | 2092 | Y2092C [6275A>G] | |
41 | 2155 | L2155S [6464T>C] |
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
BRAF | 15 | 600 | V600E [1799A>T] |
EGFR | 19 | 746, 747 | E746_A750del [2235_2249del, 2236_2250del], E746_S752>V [2237_2255delinsT], L747_A750>P [2239_2248delinsC], L747_T751del [2240_2254del], L747_P753>S [2240_2257del] |
20 | 790, 797 | T790M [2369C>T], C797S [2389T>A, 2390G>C] | |
21 | 858, 861 | L858R [2573T>G], L861Q [2582T>A] | |
KRAS | 2 | 12, 13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D[35G>A], G12A [35G>C], G12V [35G>T], G13D [38G>A] |
3 | 61 | Q61L [182A>T], Q61H [183A>T, 183A>C] |
This OncoBEAM Multigene Test is also available as KRAS – NRAS only. For more information contact your local Key Account Manager or drop us a line via info@sysmex-inostics.com
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
BRAF | 15 | 600 | V600E [1799T>A] |
KRAS | 2 | 12,13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D [35G>A], G12A [35G>C], G12V [35G>T], G13D [38G>A] |
3 | 59, 61 | A59T [175G>A], Q61R [182A>G], Q61K [181C>A] | |
4 | 117, 146 | K117N [351A>C, 351A>T],A146T [436G>A], A146V [437C>T] | |
NRAS | 2 | 12,13 | G12S [34G>A], G12R [34G>C], G12C [34G>T], G12D [35G>A], G12A [35G>C], G12V [35G>T], G13R [37G>C], G13D [38G>A], G13V [38G>T] |
3 | 59, 61 | A59T [175G>A], Q61H [183A>C, 183A>T], Q61L [182A>T] | |
4 | 117, 146 | K117N [351C>A, 351A>T], A146T [436C>A] |
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
BRAF | 15 | 600 | V600E [1799T>A] |
NRAS | 3 | 61 | Q61H [183A>C, 183A>T], Q61R [182A>G], Q61L [182A>T], Q61K [181C>A] |
Genes | Exons | Codon(s) | Mutations [Nucleotide Change] |
---|---|---|---|
IDH1 | 4 | 132 | R132S [394C>A], R132G [394C>G], R132C [394C>T], R132H [395G>A], R132L [395G>T] |
IDH2 | 4a | 140 | R140W [418C>T], R140Q [419G>A], R140L [419G>T] |
4b | 172 | R172K [515G>A], R172M [515G>T] |
Germany: Sysmex Inostics GmbH, Falkenried 88, D-20251 Hamburg, Germany. +49 40- 325907-0
United States: Sysmex Inostics, Inc., 1812 Ashland Ave Suite 500, Baltimore, Maryland 21205, USA. +1-855-BEAM-DNA (232-6362)
Japan: Sysmex Corporation, 1-5-1 Wakinohama-Kaigandori, Chuo-ku, Kobe 651-0073, Japan. +81 78 265-0500