OncoBEAM mutation testing

Our OncoBEAM tests utilize BEAMing technology (Beads, Emulsions, Amplification, & Magnetics), which is an ultra-sensitive method ideal for ctDNA analysis that employs digital PCR and flow cytometry for reliable detection of rare mutant molecules among an abundance of wildtype molecules.

OncoBEAM is one of the most established technology platforms for liquid biopsy, having been used to advance both clinical validity and utility of plasma-based detection for various clinically-relevant mutations across cancer types such as non-small cell lung cancer, colorectal cancer, and estrogen receptor-positive/ HER2-negative breast cancer.

We offer the following OncoBEAM services to support development of targeted therapies, as well as exploration of novel clinical applications for ctDNA such as molecular monitoring of minimal/measurable residual disease.

Single Gene Testing

If you are interested in specific genes, choose your analytes gene-wise.

AKT
ALK
AR
BRAF
EGFR
ESR1
HRAS
IDH1
IDH2
KRAS
NRAS
PIK3CA
ROS1

Gene Panel Testing

OncoBEAM Tests No. of Mutations Mutations Identified and Nucleotide Changes No. of Amplicons Assay Validation Status
OncoBEAM Breast Cancer Panel CLIA, GCP, RUO
AKT1 1 E17K 1
g49a
ESR1 12 E380Q, S463P, V534E, P535H, L536H, L536P, L536R, L536Q, Y537N, Y537S, Y537C, D538G 3
g1138c, t1387c, t1601a, c1604a, t1607a, t1607c, t1607g, tc1607-08ag, t1609a, a1610c, a1610g, a1613g
PIK3CA 9 C420R, E542K, E545G, E545K, Q546K, M1043I, H1047R, H1047L, H1047Y 3
t1258c, g1624a, a1634g, g1633a, c1636a, g3129t, a3140g, a3140t, c3139t
OncoBEAM Breast Cancer add ons RUO
PIK3CA 9 R88Q, R93W*, R93Q, K111E, K111N*, G118D, E365K 3
g263a, c277g, c277t, g278a, a331g, g333c, g333t, g353a, g1093a
OncoBEAM Lung Cancer Panel 1 CLIA, RUO
BRAF 1 V600E 1
t1799a
EGFR 11 E746_A750del*, E746_S752>V, L747_A750>P, L747_T751del, L747_P753>S, T790M, C797S*, L858R, L861Q 3
2235-49D, 2236-50D, 2237-55Dt, 2239-48Dc, 2240-54D, 2240-57D, c2369t, t2389a, g2390c, t2573g, t2582a
KRAS 10 G12S, G12R, G12C, G12D, G12A, G12V, G13D, Q61L, Q61H* 2
g34a, g34c, g34t, g35a, g35c, g35t, g38a, a182t, a183c, a183t
OncoBEAM Lung Cancer add on RUO
BRAF 1 V600K 1
gt1798-99aa
OncoBEAM Lung Cancer Panel 2 GCP, RUO
ALK 17 1151_1152insT, L1152R, C1156Y, I1171N*, I1171T, I1171S, F1174C, F1174L, V1180L, L1196M, L1198F, G1202R, D1203N, S1206Y, G1269A, R1275Q 5
3453-54inſACG, t3455g, g3467a, t3512a, tc3512-13at, t3512c, t3512g, t3521g, c3522a, g3538c, c3586a, c3592t, g3604a, g3607a, c3617a, g3806c, g3824a
ROS1 3 G2032R, Y2092C, L2155S 2
g6094a, a6275g, t6464c
OncoBEAM Colorectal Cancer Panel 1 CLIA, GCP, RUO
BRAF 1 V600E 1
t1799a
KRAS 15 G12S, G12R, G12C, G12D, G12A, G12V, G13D, A59T, Q61H*, Q61L, K117N*, A146T, A146V 4
g34a, g34c, g34t, g35a, g35c, g35t, g38a, g175a, a183c, a183t, a182t, a351c, a351t, g436a, c437t
NRAS 18 G12S, G12R, G12C, G12D, G12A, G12V, G13R, G13D, G13V, A59T, Q61H*, Q61R, Q61L, Q61K, K117N*, A146T 3
g34a, g34c, g34t, g35a, g35c, g35t, g37c, g38a, g38t, g175a, a183c, a183t, a182t, a182g, c181a, g351c, g351t, g436a
OncoBEAM Colorectal Cancer add ons GCP, RUO
BRAF 1 V600K 1
gt1798-99aa
HRAS 2 Q61R, Q61L 1
a182g, a182t
OncoBEAM Colorectal Cancer Panel 2 RUO
AKT1 1 E17K 1
g49a
BRAF 2 V600E, V600K 1
t1799a, gt1798-99aa
EGFR 18 G719C, G719S, G719A, E746_A750del*, E746_T751>A, E746_S752>V, L747_A750>P*, L747_T751>P, L747_S752del, L747_T751del, L747_P753>S, T790M, C797S*, L858R, L861Q 4
g2155t, g2155a, g2156c, 2235-49D, 2236-50D, 2237-51D, 2237-55Dt, 2238-48Dgc, 2239-48Dc, 2239-51Dc, 2239-56D, 2240-54D, 2240-57D, c2369t, t2389a, g2390c, t2573g, t2582a
KRAS 13 G12S, G12R, G12C, G12D, G12A, G12V, G13D, A59T, Q61H*, Q61L, A146T, A146V 3
g34a, g34c, g34t, g35a, g35c, g35t, g38a, g175a, a183c, a183t, a182t, g436a, c437t
NRAS 6 A59T, Q61H*, Q61K, Q61L, Q61R 1
g175a, a183c, a183t, c181a, a182t, a182g
PIK3CA 8 E542K, E545G, E545K, Q546K, M1043I, H1047R, H1047L, H1047Y 2
g1624a, a1634g, g1633a, c1636a, g3129t, a3140g, a3140t, c3139t
OncoBEAM Melanoma Panel GCP, CLIA, RUO
BRAF 2 V600E, V600K 1
t1799a, gt1798-99aa
NRAS 5 Q61H*, Q61R, Q61L, Q61K 1
c181a, a182t, a182g, a183t, a183c
OncoBEAM AML/Glioma Panel GCP, RUO
IDH1 5 R132S, R132G, R132C, R132H, R132L 1
c394a, c394g, c394t, g395a, g395t
IDH2 5 R140W, R140Q, R140L, R172K, R172M 2
c418t, g419a, g419t, g515a, g515t
OncoBEAM Prostate Panel GCP, CLIA, RUO
AR 16 L702H, L702Q***, V716M, W742L, W742C, H875Y, F877L**, T878A, T878S, M896V, M896T 3
t2105a, ctc2104-6acc, ctc2104-6acg, ctc2104-6act, ctc2104-6aca, g2148a, g2225t, g2226t, c2623t, t2629c, c2631a, c2631g, a2632g, c2633g, a2686g, t2687c
OncoBEAM Pancreatic Cancer Panel GCP, CLIA, RUO
KRAS 10 G12S, G12R, G12C, G12D, G12A, G12V, G13D, Q61H*, Q61L 2
g34a, g34c, g34t, g35a, g35c, g35t, g38a, a183c, a183t, a182t